Detection of antigen/antibody of Streptococcus pneumoniae and its application in etiological diagnosis of pneumonia/meningitis / 中华实用儿科临床杂志

ABSTRACT

Pneumonia is a common disease and a leading cause of death in children.Bacterial meningitis is a severe infectious disease in children, featured by high morbidity, high mortality, and high incidence of sequelae. Streptococcus pneumoniae (SP)is the main pathogenic bacteria causing community-acquired pneumonia, otitis media, sepsis, bacterial meningitis and other bacterial infectious diseases in children.The pathogen of SP should be identified before the rational use of antibiotics in clinical practice.Bacterial culture method is still the " gold standard" for the identification of SP infection pathogen, but it is not applicable to the rapid detection of SP due to the shortcomings of a low positive rate and being time consuming.Immunochromatographic tests, enzyme-linked immunosorbent tests, latex particle agglutination tests and other immunological methods have the advantages of fast detection, strong specificity, high sensitivity, and easy operation, and they are free from the influence of antibacterial agents, so they are supplement to the bacterial culture method for detection of SP infection.