Effect of interleukin-6/signal transducer and activator of transcription 3 signaling pathway on heart repair / 中华实用儿科临床杂志

ABSTRACT

Interleukin-6 (IL-6) is involved in the repair of various tissues.As a key transcription factor in IL-6 pathway, signal transducer and activator of transcription 3(STAT3) is required for heart protection.By inducing STAT3 activation, IL-6 signaling pathway could repair the cardiac damage in the healing process of many kinds of heart diseases, including cardiac injury, myocarditis and heart failure.Therefore, researches on the effect of IL-6/STAT3 pathway on heart repair has potential therapeutic implications for heart diseases.