Progress of metabonomics in etiological diagnosis of community acquired pneumonia / 中国小儿急救医学

ABSTRACT

Community acquired pneumonia (CAP) is an important cause of death in children under five years old.Viruses and bacteria are common causes.At present, accurate diagnosis of the pathogen of cap in children is still a clinical challenge.Clinical diagnosis of pathogens mainly through the collection of various samples (such as nasopharyngeal swab, sputum, blood, body fluids, etc.) for pathogen detection (such as antigen, antibody, culture, polymerase chain reaction (PCR) detection). Different samples and different detection methods have their own advantages and disadvantages, especially in the diagnosis of viral pneumonia and bacterial pneumonia, which lead to great differences in treatment measures.In order to identify different pathogens early and reduce the irrational use of antibiotics, clinicians and researchers are still exploring methods regarding early accurate pathogen diagnosis.Metabonomics is a rapidly developing field, which aims to identify and quantify the concentration changes of all metabolites or metabonomics in model systems.Most disease states are related with metabolic homeostasis.Metabonomics can provide clues for the discovery of new biomarkers, and also be used for the study of infections caused by different pathogens.Non targeted metabonomics analysis provides a new diagnostic approach for the etiology of cap in children.