Research progress in tumor microenvironment of pancreatic cancer / 中华消化外科杂志

ABSTRACT

Pancreatic cancer is an aggressive malignant tumor with poor prognosis.On the one hand,it has a narrow therapeutic window due to the lack of specific markers and obvious clinical symptoms.Once diagnosed,it has often developed to an advanced stage.On the other hand,located in a vital region of the body,pancreatic operation is difficult and the postoperative recurrence rate is high.Therefore,surgical treatment is only suitable for a small number of early patients.Pancreatic cancer has a tumor microenvironment with the characteristic of dense stroma,hypoxia,paucity of blood vessels and highly immunosuppression.It is often insensitive to traditional radiation and chemotherapy.Therefore,strategies targeting on tumor microenvironment have a potential prospect.This article reviews the research progress in tumor microenvironment of pancreatic cancer,in order to provide the references in the further research and treatment of oancreatic cancer.