Influence of Repeated Senna Laxative Use on Skin Barrier Function in Mice
Annals of Dermatology
;
: 414-421, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-86520
ABSTRACT
BACKGROUND:
Senna, one of the major stimulant laxatives, is widely used for treating constipation. Chronic senna use has been reported to be associated with colonic disorders such as melanosis coli and/or epithelial hyperplasia. However, there is no obvious information on the influence of chronic senna use on organs except for the intestine.OBJECTIVE:
To clarify the influence of senna laxative use on skin barrier function by repeated senna administration.METHODS:
Eight-week-old male hairless mice received senna (10 mg/kg/day) for 21 days. After administration, we evaluated transepidermal water loss (TEWL), and investigated the biomarkers in plasma and skin using protein analysis methods.RESULTS:
Fecal water content on day seven was significantly increased; however, on day 21, it was significantly decreased after repeated senna administration. In the senna-administered group, TEWL was significantly higher compared to the control on days seven and 21. Plasma acetylcholine concentration and NO2 −/NO3 − were increased on days seven and 21, respectively. In skin, tryptase-positive mast cells and inducible nitric oxide synthase (iNOS)-positive cells were increased on days seven and 21, respectively. The increase of TEWL on days seven and 21 was suppressed by the administration of atropine and N(G)-nitro-L-arginine methyl ester, respectively.CONCLUSION:
It was suggested that diarrhea or constipation induced by repeated senna administration caused the impairment of skin barrier function. There is a possibility that this impaired skin barrier function occurred due to degranulation of mast cells via cholinergic signals or oxidative stress derived from iNOS.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Atropina
/
Extrato de Senna
/
Pele
/
Água
/
Biomarcadores
/
Acetilcolina
/
Colo
/
Estresse Oxidativo
/
Constipação Intestinal
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Annals of Dermatology
Ano de publicação:
2017
Tipo de documento:
Artigo
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