Comparative analysis of tremor characteristics between essential tremor with Parkinson disease and pure Parkinson's disease or pure essential tremor / 中国医师进修杂志

ABSTRACT

Objective:To compare and analyze the tremor characteristics between essential tremor (ET) with Parkinson disease (PD) and pure PD or pure ET.Methods:From January 2015 to June 2019 in Rizhao People′s Hospital of Shandong Province, 35 patients with PD and ET (observation group), 35 patients with pure PD (control group Ⅰ) and 35 patients with pure ET (control group Ⅱ) were selected. Tremor analysis were performed in all the patients, and the results of tremor analysis were compared statistically.Results:There were significant differences in the proportion of static tremor, postural tremor and the recurrence time of tremor among control group Ⅰ, control group Ⅱ and observation group 80.0% (28/35) vs. 20.0% (7/35) and 65.7% (23/35), 65.7% (23/35) vs. 100.0% (35/35) and 88.6% (31/35), (10.2±2.6) s vs. (2.5 ± 1.3) s and (7.6 ± 2.9) s ( P < 0.05). The tremor frequencies of control group Ⅰ, control group Ⅱ and observation group at rest were (5.5 ± 0.7), (7.2 ± 1.3) and (6.2 ± 1.1) Hz, and at posture were (6.2 ± 2.0), (8.3 ± 1.9) and (6.5 ± 1.3) Hz, respectively, with statistically significant differences among the three groups ( F = 6.881 and 7.984, P < 0.05). The proportion of electromyography alternating contractions of the active and antagonistic muscles of control group Ⅰ, control group Ⅱ and observation group at rest were 76.7% (23/30), 0, 34.6% (9/26), and at posture were 53.3% (16/30), 20.0% (7/35), 26.9% (7/26), with statistically significant differences among the three groups ( χ2 = 16.186 and 7.650, P < 0.05). The above data of the observation group were in the middle level. The working characteristic curve was used to analyze the efficacy of PD with ET, PD and ET, and the area under the curve was 0.654, 0.756 and 0.771, respectively. Conclusions:ET with PD has both the characteristics of pure PD or pure ET and the unique characteristics. Tremor analysis can objectively identify the electromyography alternating contractions at rest of PD with ET.