Clinical study of Naoxintong capsule combined with levamlodipine tablets in the treatment of essential hypertension / 中国基层医药

ABSTRACT

Objective:To investigate the clinical effect of Naoxintong capsule combined with levamlodipine tablets in the treatment of essential hypertension.Methods:From February 2018 to February 2019, 182 cases of essential hypertension were selected in Jiangshan Hospital of Traditional Chinese Medicine and divided into treatment group (91 cases) and control group (91 cases) according to the random digital table.The treatment group was treated with Naoxintong capsule combined with levamlodipine tablets, while the control group was treated with levamlodipine tablets.Both two groups were treated for 12 weeks.The therapeutic effects, blood pressure, urinary microalbumin (MAU), vascular endothelial function and inflammatory mediators before and after treatment were compared between the two groups.Results:The total effective rate of the treatment group[91.21%(83/91)]was higher than that of the control group[79.12%(72/91)](χ 2=5.262, P<0.05). After treatment, SBP[(132.36±8.27)mmHg], DBP[(84.35±5.32)mmHg]and MAU[(26.47±5.47)mg/L] in the treatment group were lower than those in the control group[(139.62±6.58)mmHg, (89.74±4.12)mmHg and (33.82±3.76)mg/L]( t=6.553, 7.641, 10.563, all P<0.05). The NO[(52.17±5.36)μmol/L]and FMD[(7.98±0.42)%] in the treatment group were higher than those in the control group[(41.09±7.28)μmol/L and (6.79±0.37)%], while ADMA[(0.23±0.06)μmol/L]in the treatment group was lower than that in the control group[(0.34±0.07)μmol/L], the differences were statistically significant( t=11.692, 20.281, 11.382, all P<0.05). The serum levels of IL-1[(128.32±13.25)ng/L] and IL-4[(24.35±5.71)ng/L] in the treatment group were lower than those in the control group[(173.79±23.19)ng/L and (32.19±6.57)ng/L], while the serum IL-10 level[(23.54±3.25)ng/L] in the treatment group was higher than that in the control group[(18.09±4.86)ng/L], the differences were statistically significant( t=16.240, 8.592, 8.892, all P<0.05). Conclusion:Naoxintong capsule combined with levamlodipine tablets is effective in the treatment of essential hypertension, which can reduce MAU, improve vascular endothelial dysfunction and alleviate inflammation.