Effect of Shufeng Xuanfei Zhike decoction on cough variant asthma / 中国基层医药

ABSTRACT

Objective:To observe the clinical effect of Shufeng Xuanfei Zhike decoction on cough variant asthma.Methods:A total of 86 patients with cough variant asthma admitted to the Second People's Hospital of Yuyao from August 2016 to July 2017 were selected and divided into two groups according to the random digital table method, with 43 cases in each group.The control group was given conventional treatment, and the observation group was given Shufeng Xuanfei Zhike decoction combined with conventional treatment.The clinical efficacy, symptom score, inflammatory factors and adverse reactions were observed.Results:The total effective rate of the observation group was 95.35%(41/43), which was higher than 79.07%(34/43) of the control group, the difference was statistically significant(χ 2=5.108, P=0.024). The symptom scores of cough[(1.23±0.56)points], sputum[(0.66±0.27)points], nasal congestion[(0.64±0.30)points], shortness of breath[(0.55±0.18)points] and pharyngeal itch[(0.70±0.24)points] in the observation group were lower than those in the control group[(2.73±0.85)points, (1.18±0.52)point, (1.18±0.45)point, (1.02±0.47)points, (1.38±0.58)points], the differences were statistically significant( t=9.663, 5.820, 6.547, 6.124, 7.104, all P<0.05). After treatment, the levels of interleukin 4, interleukin 6, hypersensitive C-reactive protein and tumor necrosis factor alpha in the observation group were (5.26±1.68)ng/L, (8.35±1.00)ng/L, (2.08±0.21)mg/L, (0.75±0.22)ng/L, respectively, which were lower than those in the control group[(8.73±1.77)ng/L, (12.30±1.24)ng/L, (4.33±0.38)mg/L, (1.75±0.34)ng/L], and the differences were statistically significant( t=9.324, 16.260, 33.983, 16.192, all P<0.05). The level of interleukin 10 in the observation group [(29.94±8.88)ng/L] was higher than that in the control group[(22.66±8.37)ng/L]( t=3.912, P<0.05). No obvious adverse reactions were observed in both two groups. Conclusion:Shufeng Xuanfei Zhike decoction is safe and effective in the treatment of patients with cough variant asthma.