Effects of different blood purification methods on inflammatory factors and nutritional status in patients with end-stage renal disease / 中国基层医药

ABSTRACT

Objective:To investigate the effect of different blood purification methods on inflammatory factors and nutritional status in patients with end-stage renal disease.Methods:From June 2017 to June 2019, 82 patients with end-stage renal disease were enrolled in Zhejiang Xin'an International Hospital.They were divided into group A and group B according to the random digital table method, with 41 cases in each group.High flux hemodialysis was used in group A, and routine hemodialysis was used in group B. The changes of inflammatory factors, nutritional status, renal function, parathyroid hormone(PTH) and complications before and 6 months after dialysis were compared between the two groups.Results:The levels of serum TNF-α[(153.24±20.98)ng/L], hs-CRP[(15.46±2.53)mg/L] and IL-6[(10.35±2.83)ng/L] in group A were lower than those in group B[(192.37±16.47)ng/L, (21.65±2.41)mg/L and (16.74±2.41)ng/L]( t=9.394, 11.343, 11.007, all P<0.05). The serum SF[(268.93±15.31)μg/L], ALB[(37.84±1.16)g/L] and Hb[(107.25±10.24)mg/L] in group A were higher than those in group B[(237.18±8.97)mg/L, (33.76±1.35)g/L and (95.32±7.53)mg/L]( t=11.457, 14.678, 6.010, all P<0.05). The serum creatinine[(146.71±17.37)μmol/L] and urea nitrogen[(14.37±2.18)mmol/L] in group A were lower than those in group B[(226.38±23.15)μmol/L and (20.93±2.63)mmol/L]( t=17.626, 12.296, all P<0.05). The serum PTH[(409.27±25.48)ng/L] in group A was lower than that in group B[(501.32±41.27)ng/L]( t=12.152, P<0.05). The incidence of complications in group A was lower than that in group B[12.20%(5/41) vs.39.02%(16/41), χ 2=7.746, P<0.05]. Conclusion:High flux hemodialysis is effective in the treatment of end-stage renal disease, which can reduce the micro inflammation, improve the nutritional status and reduce the complications.