Effect of flunarizine combined with carbamazepine in the treatment of migraine / 中国基层医药

ABSTRACT

Objective:To explore the effect and safety of flunarizine combined with carbamazepine in the treatment of migraine.Methods:From January 2018 to December 2018, 88 migraine patients treated in Yuyao People's Hospital were divided into control group ( n=44) and observation group ( n=44) according to different treatment methods.The control group was given flunarizine, and the observation group was treated with flunarizine combined with carbamazepine.The clinical efficacy and the incidence of adverse reactions were compared between the two groups through evaluation of the SF-36 scale score before and after treatment and the main cerebral arterial blood flow velocity. Results:The total effective rate in the observation group was significantly higher than that in the control group (90.91% vs.72.73%, χ 2=5.437, P<0.05), and the incidence of adverse reactions had no statistically significant difference between the two groups (15.91% vs.11.36%, P>0.05). The scores of the SF-36 scale in the observation group after treatment were significantly higher than those in the control group [PF (86.15±8.24)points vs.(93.78±9.73)points; RP (67.15±12.96)points vs.(87.93±13.78)points; BP (59.59±15.75)points vs.(73.25±18.34)points; GH (58.92±14.83)points vs.(69.12±17.93)points; VT (64.98±15.45)points vs.(72.48±16.78)points; SF (78.62±14.91)points vs.(87.26±15.72)points; RE (60.25±18.45)points vs.(69.12±15.72)points; MH (74.91±16.45)points vs.(87.12±17.93)points], the cerebral arterial blood flow velocity was significantly lower than the control group [ACA (57.12±8.94)cm/s vs.(52.73±9.02)cm/s; MCA (75.82±11.92)cm/s vs.(63.09±11.25)cm/s; PCA (49.87±10.64)cm/s vs.(45.10±9.25)cm/s; VA (46.20±4.02)cm/s vs.(44.12±4.03)cm/s; BA (50.10±6.95)cm/s vs.(46.52±7.21)cm/s] (PF t=3.969, RP t=7.287; BP t=3.748; GH t=2.908; VT t=2.181; SF t=2.645; RE t=2.427; MH t=3.329; ACA t=2.293; MCA t=5.152; PCA t=2.244; VA t=2.424; BA t=2.371, P<0.05). Conclusion:Flunarizine combined with carbamazepine can significantly improve the treatment effect of migraine, improve the quality of life and cerebral arterial blood flow velocity of patients, and has high safety.