Effect of Kouyanqing granule combined with ornidazole on the expression of HMGB1, TNF-α, IL-17 and IL-23 in patients with chronic periodontitis / 中国基层医药

ABSTRACT

Objective:To investigate the effect of Kouyanqing granule combined with ornidazole on the expression of high mobility group protein B1 (HMGB1), tumor necrosis factor-α (TNF-α), interleukin-17 (IL-17) and interleukin-23 (IL-23) in patients with chronic periodontitis.Methods:From October 2018 to October 2019, 162 patients with chronic periodontitis admitted to the First People's Hospital of Xiaoshan District were divided into observation group (81 cases) and control group (81 cases) according to the random digital table method.The control group was treated with ornidazole, and the observation group was treated with Kouyanqing granules on the basis of the control group.The course of treatment in both two groups was 4 weeks.The changes of plaque index (PLI), probing depth of periodontal pocket (PD), bleeding index (BI), HMGB1, TNF-α, IL-17 and IL-23 and adverse reactions were compared before and after treatment.Results:The total effective rate of the observation group (91.36%) was higher than that of the control group (77.78%) (χ 2=5.723, P<0.05). The PLI(0.93±0.16), PD[(3.15±0.37)mm] and BI(1.35±0.24) in the observation group were lower than those in the control group [(1.42±0.24), (4.28±0.45)mm and (2.18±0.28)] ( t=15.289, 17.457, 20.256, all P<0.05). The levels of HMGB1 [(0.78±0.13)μg/L], TNF-α[(3.10±0.32)μg/L], IL-17[(368.19±24.31)ng/L] and IL-23[(7.63±0.89)ng/L] in the observation group were lower than those in the control group [(0.96±0.10)μg/L, (4.34±0.46)μg/L, (457.32±21.35)ng/L and (10.32±1.25)ng/L] ( t=9.877, 19.916, 24.793, 15.777, all P<0.05). The incidence of adverse reactions in the observation group (6.17%) was lower than that in the control group (17.28%) (χ 2=4.830, P<0.05). Conclusion:Kouyanqing granule combined with ornidazole is effective in the treatment of chronic periodontitis.It can reduce the levels of HMGB1, TNF-α, IL-17 and IL-23, and has few adverse reactions.