Effect of compound glycyrrhizin on inflammatory factor and immune function in children with Henoch-Schonlein purpura / 中国基层医药

ABSTRACT

Objective:To investigate the effect of compound glycyrrhizin on inflammatory factors and immune function in children with Henoch-Schonlein purpura (HSP).Methods:From March 2017 to December 2018, 75 children with clinically confirmed HSP in Shanxi Grand Hospital were divided into two groups by random number table method.The control group (38 cases) was given routine basic treatment, while the observation group (37 cases) was given intravenous drip of compound glycyrrhizin injection once a day.Both two groups were treated for 14 days.The curative effect and the differences of inflammatory factors[interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), procalcitonin (PCT), C-reactive protein (CRP)], immune function[CD 4+ , CD 4+ /CD 8+ , immunoglobulin G (IgG), immunoglobulin A (IgA)] before and after treatment were observed. Results:The effective rate of the observation group was higher than that of the control group (94.59% vs.76.32%, χ 2=5.005, P<0.05). The levels of IL-6, TNF-α, PCT, CRP in the observation group after treatment were lower than those in the control group[(3.52±1.46)ng/L vs.(5.12±1.39)ng/L, (2.31±0.12)μg/L vs.(4.21±0.29)μg/L, (1.25±0.46)μg/L vs.(3.12±0.82)μg/L, (5.98±1.19)mg/L vs.(9.55±3.82)mg/L, t=4.861, 6.891, 12.135, 5.433, all P<0.05]. The levels of IgG, IgA, CD 4+ , CD 4+ /CD 8+ in the observation group were higher than those in the control group[(14.65±2.57)g/L vs.(12.92±2.82)g/L, (5.26±2.57)g/L vs.(4.16±1.64)g/L, (43.94±10.71)% vs.(38.02±10.63)%, (2.90±0.61)% vs.(2.02±0.53)%, t=2.775, 2.216, 2.402, 6.675, all P<0.05]. Conclusion:Compound glycyrrhizin can effectively reduce inflammation in children with HSP, improve immune function and improve clinical efficacy.