Research progress on polarization regulation mechanism of alveolar macrophages in acute lung injury / 中华危重病急救医学

ABSTRACT

Acute lung injury (ALI) is a common clinical critical disease, with a high mortality. The imbalance of alveolar macrophage (AMs) polarization plays an important role in the occurrence and development of ALI inflammation. The study of the regulation mode and mechanism of macrophage polarization can provide more theoretical basis for clinical prevention and treatment of ALI. In recent years, it has been found that epigenetics and immune metabolic microenvironment can affect the macrophage polarization and the immune inflammatory response of ALI. In this review, the progress of macrophage polarization, epigenetics and immune metabolism regulating macrophage polarization, the relationship between macrophage polarization and ALI were summarized, so as to clarify the effect and significance of regulating macrophage polarization on ALI, and provide new ideas for the prevention and treatment of ALI in clinic.