Comparison of cognitive impairment in patients with intracranial artery severe stenosis or occlusion in anterior and posterior circulations / 中华行为医学与脑科学杂志

ABSTRACT

Objective:To investigate the impact of severe stenosis or occlusion of intracranial artery in anterior and posterior circulation on cognitive function in patients.Methods:Patients with Alberta stroke program early CT score(ASPECTS) and posterior circulation ASPECTS(pc-ASPECTS) of 10 were selected, and neuropsychological assessments were performed in 30 patients with intracranial artery severe stenosis or occlusion in anterior posterior circulation (anterior circulation group)and 23 patients with intracranial artery severe stenosis or occlusion in posterior circulation(posterior circulation group) and 53 control subjects using MMSE, MoCA and multidimensional psychological assessment system.Results:The scores of time orientation(control group 5.00(5.00, 10.00), anterior circulation group 5.00(5.00, 5.00), posterior circulation group 5.00(5.00, 5.00)), attention (control group 6.00(5.00, 6.00), anterior circulation group 5.00(4.00, 6.00), posterior circulation group 5.00(4.00, 6.00)) and word discrimination test (control group 70.00(60.00, 82.00), anterior circulation group 48.00(20.50, 67.50), posterior circulation group 53.50(33.25, 75.25)) were significantly lower in patients of anterior circulation group and posterior circulation group than those of control group(all P<0.05); The scores of memory(control group 3.00(2.00, 3.00), anterior circulation group 2.00(1.00, 3.00), MMSE(control group 29.00(28.00, 30.00), anterior circulation group 28.00(26.75, 29.00)) and simple subtraction(control group 72.00(53.50, 85.50), anterior circulation group 53.50(37.00, 73.00)) were significantly lower in patients of anterior circulation group than those of control group(all P<0.05); The scores of visuospatial executive function(control group 4.00(3.00, 5.00), posterior circulation group 3.00(2.00, 4.00)) and digital sequence reasoning(control group 74.50(51.50, 83.00), posterior circulation group 42.00(28.00, 70.00)) were significantly lower in patients of posterior circulation group than those of control group(all P<0.05); The scores of spatial working memory test(control group 77.50(51.75, 89.00), anterior circulation group 56.50(34.00, 72.50), posterior circulation group 31.00(18.50, 58.00))were significantly lower in patients of posterior circulation group than those of the other two groups(all P<0.05). Conclusion:Severe stenosis or occlusion of intracranial arteries in anterior and posterior circulation is associated with cognitive impairment in patients.Vascular lesions in different parts can lead to cognitive impairment in different aspects.