Correlation between serum complement C1q, thyroid hormone and depression / 中华行为医学与脑科学杂志

ABSTRACT

Objective:To explore the correlation between serum C1q, thyroid hormone (serum FT 3, FT 4, TSH) and depression by detecting the difference of serum C1q, thyroid hormone (serum FT 3, FT 4, TSH) between depression patients and normal people. Methods:A total of 275 depressive patients(depression group) and 275 healthy controls(healthy group) were recruited.The serum levels of C1q, FT 3, FT 4 and TSH were compared between the two groups.The serum levels of C1q, FT 3, FT 4 and TSH in depression patients with different age, gender, course of disease and HAMD were compared.Further regression analysis was used to evaluate the effects of serum C1q, FT 3, FT 4 and TSH levels on the incidence and severity of depression in patients with depression. Results:Serum C1q, FT 3, TSH of depression group(C1q 203(165, 239)mg/L, FT 3 (4.39±0.70)pmol/L, TSH 1.69(1.17, 2.46)mIU/L) were significantly lower than those of healthy group(C1q (236.25±27.06)mg/L, FT 3 4.61(4.29, 4.95)pmol/L, TSH 2.04(1.42, 3.01)mIU/L)(all P<0.01). Compared with the serum indexes in depression group, the level of C1q and TSH in men(C1q 188.00 (164.00, 221.00) mg/L, TSH 1.52(1.13, 2.16)mIU/L) were significantly lower than those in women(C1q 213.00 (168.25, 247.75) mg/L, TSH 1.85(1.28, 2.57)mIU/L)( P<0.05), and the level of FT 3 and FT 4 in men(FT 3 4.64 (4.23, 5.06) pmol/ L, FT 4 16.76(15.05, 18.20)pmol/L) were significantly higher than those in women (FT 3 4.34 (3.82, 4.72) pmol/L, FT 4 15.92(14.35, 17.40)pmol/L). Serum C1q ( B=-0.020, P<0.01, OR95% CI 0.980 (0.975, 0.985)), FT 3 ( B=-0.576, P<0.01, OR95% CI 0.562 (0.408, 0.775)), TSH ( B=-0.274, P<0.01, OR95% CI 0.761 (0.648, 0.893)) level were the influencing factors of depression. Conclusion:Serum C1q and thyroid hormone may be involved in the pathogenesis of depression, and may be affected by gender factors.