Meta-analysis of the relationship between the polymorphism of ACE and TNF-α gene and the susceptibility of sarcoidosis / 中国医师杂志

ABSTRACT

Objective To evaluate the relationship between angiotensin converting enzyme (ACE) and tumor necrosis factors-α (TNF-α) gene polymorphism and sarcoidosis.Methods Meta analysis was carried out by retrieving the studies published up to July 2018 to evaluate the relationship between ACE and TNF-α gene polymorphism and sarcoidosis.RevMan 5.3 and Stata 12.0 software were used to analyze the combined OR value and 95％ confidence interval (95％ CI) by recessive model and dominant model.The stability of the results was judged by ethnic subgroup analysis and sensitivity analysis.Results A total of 28 articles and 30 studies met the inclusion criteria,including 7 888 cases,2 992 cases of sarcoidosis and 4 896 healthy controls.No significant association was found between ACE I/D and sarcoidosis using any model (P ＞ 0.05).TNF-α-308A/G was significantly associated with sarcoidosis risk (OR =1.34,95％ CI =1.13-1.58,P =0.0007).Ethnic subgroup analysis showed that the results were significantly different in both the Caucasians (OR =1.36,95％ CI =1.13-1.64,P =0.001) and the Asians (OR =4.88,95％ CI =1.43-16.99,P =0.01).Conclusions The meta-analysis identified that AA/AG genotypes at TNF-α-308 were associated with susceptibility to sarcoidosis.However,no significant correlation was found between ACE I/D and the susceptibility of sarcoidosis.