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Increase in the Serum Parathyroid Hormone Level During a Bisphosphonate Drug Holiday
Journal of Bone Metabolism ; : 217-222, 2014.
Artigo em Inglês | WPRIM | ID: wpr-86727
ABSTRACT
After discontinuation of bisphosphonate therapy, an antiresorptive effect and antifracture protection persist for an undefined period. Patients are encouraged to continue calcium and vitamin D supplementation, during a bisphosphonate drug holiday. However, assessment of adequate calcium intake during the bisphosphonate drug holiday is difficult. Therefore, we measured the serum intact parathyroid hormone (PTH) level as a surrogate marker. A premenopausal woman discontinued bisphosphonate therapy, after 7.5 years of treatment. Two months later, blood calcium and phosphorus levels were normal, serum 25-hydroxyvitamin D level was 31.3 ng/mL, but serum PTH level had increased to 94.9 pg/mL. The elemental calcium supplement dose was increased to 600 mg/day, with no change in the cholecalciferol dose (400 IU). Her serum PTH levels decreased to 49.1 after 4 months and 32.9 pg/mL after 5 months. The serum PTH level may be helpful in assessing adequate calcium intake during a bisphosphonate drug holiday.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Hormônio Paratireóideo / Fósforo / Vitamina D / Biomarcadores / Cálcio / Colecalciferol / Férias e Feriados Limite: Feminino / Humanos Idioma: Inglês Revista: Journal of Bone Metabolism Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Hormônio Paratireóideo / Fósforo / Vitamina D / Biomarcadores / Cálcio / Colecalciferol / Férias e Feriados Limite: Feminino / Humanos Idioma: Inglês Revista: Journal of Bone Metabolism Ano de publicação: 2014 Tipo de documento: Artigo