Effect of clotrimazole vaginal tablets combined with lactobacillus vaginal capsules on inflammation and oxidative stress in pregnant women with candidal vaginitis / 中国医师杂志

ABSTRACT

Objective:The effect of clotrimazole vaginal tablets combined with lactobacilli vaginal capsules on inflammatory response and oxidative stress in pregnant patients with candidal vaginitis.Methods:A prospective study of 126 patients with candidal vaginitis was randomly divided into control group and observation group, 63 cases in each group. The control group received clotrimazole vaginal tablets and the observation group received clotrimazole vaginal tablets combined with lactobacillus vaginal capsule treatment. The efficacy, inflammatory factor levels, oxidative stress and pregnancy outcomes of the two groups were observed.Results:The total clinical effective rate of the observation group was significantly higher than that of the control group (95.24% vs 80.95%, P<0.05). After treatment, the levels of tumor necrosis factor α, interleukin-6, and C-reactive protein inflammatory factors in the observation group were lower than those in the control group. The levels of superoxide dismutase and nitric oxide in the observation group were higher than those in the control group ( P<0.05), and the levels of malondialdehyde and plasma endothelin-1 were lower than those in the control group ( P<0.05). The incidence of premature delivery and premature rupture of membranes in the observation group was significantly lower than that in the control group ( P<0.05). Conclusions:Clotrimazole vaginal tablets combined with lactobacillus vaginal capsules for the treatment of pregnancy with candida vaginitis are effective and can reduce vaginal inflammation, improve oxidative stress, and reduce the occurrence of adverse pregnancy outcomes such as premature delivery and premature rupture of membranes.