Correlation analysis between MSCT scan signs and expression of VEGF in 51 patients with hepatocellular carcinoma / 中国医师杂志

ABSTRACT

Objective:To analyze the multi-slice spiral CT (MSCT) scan signs and the expression of vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC) patients.Methods:A total of 51 patients with HCC admitted to our hospital from April 2015 to December 2018 were enrolled. The VEGF positive rate, microvessel density (MVD) level, HCC VEGF positive and negative MVD levels, and MSCT were compared between HCC and paracancerous tissues. The level of angiogenesis index was scanned and the association between MSCT scan signs and VEGF and MVD was analyzed.Results:The positive rate of VEGF and MVD in HCC tissues were higher than that in adjacent tissues ( P<0.05); MVD in patients with VEGF positive HCC was higher than that in patients with VEGF negative ( P<0.05); There was no significant difference in the positive rate of VEGF and MVD between patients with lesions >5 cm and ≤ 5 cm ( P>0.05). The VEGF positive rate and MVD in patients with pseudocapsule without / incomplete were higher than those in patients with intact capsule; the VEGF positive rate and MVD in patients with high risk invasion were higher than those in patients with low risk; the VEGF positive rate and MVD in arterial blood supply were higher than those in patients with dual supply and insufficient blood supply ( P<0.05); MSCT scan showed that false capsule without / incomplete, high risk of invasion, arterial blood supply and double supply were positively correlated with VEGF and MVD, while less blood supply was negatively correlated with VEGF and MVD ( P<0.05). Conclusions:MSCT scan can accurately evaluate the size of HCC lesions, the presence of false capsule, invasion and metastasis, enhancement type, etc. No/incomplete pseudocapsule, high-risk invasion, arterial blood supply and dual supply are positively correlated with VEGF and MVD, while less blood supply is negatively correlated with VEGF and MVD. This can pro-vide a new rapid, simple and non-invasive examination method for the evaluation of tumor neovascularization and diagnosis and prognosis for HCC.