The relationship between heart rate variability and cardiac function and prognosis in patients with Parkinson′s disease and chronic heart failure / 中国医师杂志

ABSTRACT

Objective:To analyze the relationship between heart rate variability (HRV) and cardiac function and prognosis in patients with Parkinson′s disease (PD) and chronic heart failure (CHF).Methods:60 patients with PD and CHF admitted to our hospital from January 2018 to December 2019 were selected as group A. 50 patients with simple PD admitted in the same period were selected as group B , and 40 patients in the healthy control group were selected as group C. The high frequency (HF), low frequency (LF), high frequency and low frequency ratio (HF/LF), left ventricular ejection fraction (LVEF) were monitored in the three groups, and the incidence and mortality of cardiovascular events such as acute coronary syndrome, malignant arrhythmia and acute heart failure were recorded during six months follow-up.Results:The HF, HF/LF ratio and LVEF of group C were significantly higher than those of group A and B, and LF value was significantly lower than that of group A and B ( P<0.05). The HF, HF/LF ratio and LVEF of group B were significantly higher than those of group A, and LF value was significantly lower than that of group A ( P<0.05). The HF and HF/LF ratio of patients with LVEF≥50% in group A was significantly higher than those with LVEF<50%, and LF was significantly lower than those with LVEF<50% ( P<0.05). The HF and HF/LF values of the patients in group A who died and had cardiovascular events were significantly lower than those of the surviving patients and those without cardiovascular events, and the LF values were significantly higher than those of the surviving patients and those without cardiovascular events ( P<0.05). The HF and HF/LF value of group A was positively correlated with LVEF value ( r HF=0.883, rHF/ LF=0.854, P<0.05), and negatively correlated with mortality ( r HF=-0.819, rHF/ LF=-0.802, P<0.05) and cardiovascular events ( r HF=-0.736, rHF/ LF=-0.794, P<0.05) ; LF value was negatively correlated with LVEF value ( r=-0.743, P<0.05). LF value was positively correlated with mortality ( r=0.743, P<0.05) and the incidence of cardiovascular event ( r=0.750, P<0.05). Conclusions:The decrease of HRV in PD patients with CHF will weaken their cardiac function and increase their adverse prognosis. Therefore, the monitoring of HRV is helpful for the treatment and prognosis intervention in PD patients with CHF.