Correlation of serum pepsinogen and gastrin levels and tumor malignancy in patients with primary gastric cancer / 中国医师杂志

ABSTRACT

Objective:The serum levels of pepsinogen (PG) and gastrin 17 (G17) in patients with primary gastric cancer were determined, and the correlation between them and the degree of tumor malignancy was analyzed to provide a reliable basis for clinical diagnosis and treatment.Methods:The study group included 155 patients with primary gastric cancer treated in Peking University (PKU) Care Luzhong Hospital from January 2019 to January 2020, and with the same period to the hospital physical examination of 100 cases of healthy volunteers as control group. Peripheral venous blood samples were taken from all subjects for detection, and serum PG Ⅰ, PG Ⅱ, G17 level were compared and analyzed, and PG Ⅰ/PG Ⅱ (PGR) was calculated. The indexes of gastric cancer patients in different stages and tumor node metastasis (TNM) stages were analyzed, and the receiver operating characteristic (ROC) curve was drawn to analyze the efficacy of the above indicators in the diagnosis of gastric cancer.Results:The levels of PG Ⅰ and PGR in the study group were significantly lower than those in the control group ( P<0.05), and the serum level of G17 was significantly higher than that of the control group, while the difference of PG Ⅱ level was not statistically significant ( P>0.05). Based on the progress of tumor focus, serum PG Ⅰ and PGR in patients with advanced gastric cancer were significantly lower than those in patients with early gastric cancer ( P<0.05), while serum G17 level were higher in patients with early gastric cancer ( P<0.05). Based on TNM stage, serum PG Ⅰ level decreased significantly with the increase of tumor stage ( P<0.05), while serum G17 level increased significantly ( P<0.05). The ROC curve showed that the combined detection of serum PG Ⅰ, PG Ⅱ, PGR and G17 was superior to single index in the diagnosis of gastric cancer. The area under curve (AUC) of combined detection was the highest, with sensitivity and specificity of 83.87% and 76.77%, respectively. Conclusions:The expression levels of serum PG Ⅰ, PGR and G17 are correlated with the degree of malignancy of primary gastric cancer. Moreover, combined detection and diagnosis of primary gastric cancer has good efficacy and important clinical value.