Clinical Efficacy of Topical Diquafosol Tetrasodium after Laser Epithelial Keratomileusis
Journal of the Korean Ophthalmological Society
; : 1324-1330, 2015.
Article
em Ko
| WPRIM
| ID: wpr-86792
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
To evaluate the clinical effectiveness of topical diquafosol tetrasodium (DQS) after laser epithelial keratomileusis (LASEK).METHODS:
This randomized prospective study included 97 eyes of 49 patients who were scheduled for LASEK. Patients in the DQS group used both 0.3% sodium hyaluronate and 3% DQS for 3 months after surgery while patients in the control group used only 0.3% sodium hyaluronate. Corneal staining score, tear film break-up time (TF-BUT), Schirmer test and ocular surface disease index (OSDI) were evaluated before surgery and 2, 4, 8, 12 and 16 weeks after surgery.RESULTS:
There was no significant difference in visual acuity, spherical equivalent and corneal haziness between the 2 groups after surgery. Corneal staining score was significantly lower in the DQS group than in the control group 2 weeks after LASEK (p < 0.01) and increased in the control group after LASEK compared with the preoperative value (2 weeks after LASEK, p < 0.01), but decreased in the DQS group (12 and 16 weeks after LASEK, p < 0.05). TF-BUT was significantly higher in the DQS group than in the control group 2 to 16 weeks after LASEK (p < 0.01) and increased values were observed in the DQS group after LASEK compared with the preoperative value (4 to 16 weeks after LASEK, p < 0.05). The mean OSDI was significantly higher 4 to 16 weeks after LASEK in the control group than in the DQS group (p < 0.01).CONCLUSIONS:
Subjective dry eye symptoms and objective markers were worse for 4 weeks after LASEK. The use of 3% DQS for 12 weeks after surgery improved these symptoms and markers with the effect lasting 16 weeks after LASEK.Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Lágrimas
/
Síndromes do Olho Seco
/
Acuidade Visual
/
Estudos Prospectivos
/
Ceratectomia Subepitelial Assistida por Laser
/
Procedimentos Cirúrgicos Refrativos
/
Ácido Hialurônico
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Humans
Idioma:
Ko
Revista:
Journal of the Korean Ophthalmological Society
Ano de publicação:
2015
Tipo de documento:
Article