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Study of the feasibility of needle path optimization in 3D brachytherapy for cervical cancer / 中华放射肿瘤学杂志
Chinese Journal of Radiation Oncology ; (6): 215-219, 2020.
Artigo em Chinês | WPRIM | ID: wpr-868583
ABSTRACT
Objective To compare the dosimetric differences between free-hand method and virtually optimized method for implanting needles in intracavitary and interstitial combined brachytherapy (IC/IS BT) of cervical cancer,and to explore the improvement space of the existing interstitial brahcytherapy plan.Methods High-dose-rate cervical cancer IC/IS BT plans (short for Treatment-Plan) of 18 cases were retrospectively analyzed.For each treatment plan,Nucletron Oncentra 3D brachytherapy planning system was utilized to redesign the virtually optimized insertion method IC/IS BT plan (short for Optimized-Plan).Dose volume histogram was adopted to evaluate the dose distribution in high-risk clinical target areas and exposure dose to organ at risk (OAR).The plan execution efficiency between two plans was also assessed.Results Comparing these two plans,the differences in conformity and uniformity of dose distribution of the target area were statistically significant (P=0.000,0.008).The differences of D0.01 cm3,D1 cm3,D2 cm3 and D5 cm3 in bladder,rectum,sigmoid and small bowel were all statistically significant (all P<0.05).Optimized-Plan could reduce the D2 cm3 of bladder,rectum,sigmoid and small bowel by 60.41,36.43,27.53 and 12.43 cGy,respectively.The execution time for the Treatment-Plan and Optimized-Plan were (857.92±243.39) s and (804.53±239.13) s with statistical significance (P<0.001).Conclusions Compared with the free-hand method,virtually optimized method yields more conformable coverage of the target area and more uniform dose distribution.At the same time,the doses of each OAR are reduced to different degrees and the execution time of the plan is also shortened.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Radiation Oncology Ano de publicação: 2020 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Radiation Oncology Ano de publicação: 2020 Tipo de documento: Artigo