Research progress on multi-disciplinary combined therapy for locally advanced hypopharyngeal carcinoma / 中华放射肿瘤学杂志

ABSTRACT

Hypopharyngeal carcinoma is one of the worst prognosis among head and neck cancers with a reported 5-year overall survival (OS) rate of 25%-35%. Because of the important position and function of hypopharynx, the preservation of organ function and improvement of survival are equally important. Multi-disciplinary combined treatment modality is playing a more and more pivotal role. The optimal combined modalities of surgery, radiotherapy, chemotherapy and molecular targeted therapy have been constantly modified, so the survival rate and organ function preservation rate have been gradually increased. As the surge of immunotherapy, immunotherapy combined with chemoradiotherapy in the treatment of hypopharyngeal cancer has become a highlight field. In this article, the research progress on multi-disciplinary combined treatment and the future direction in the treatment of hypopharyngeal carcinoma were mainly introduced.