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The relationship between hyperuricemia and mild cognitive impairment in non-obese elderly / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism ; (12): 405-409, 2020.
Artigo em Chinês | WPRIM | ID: wpr-870053
ABSTRACT

Objective:

To determine the relationship between uric acid (UA) and mild cognitive impairment (MCI), and its potential effect on inflammation.

Methods:

450 patients with MCI diagnosed by neuropsychological scale and 450 controls with normal cognitive function were included. All subjects were≥60 years old. There were 184 obese subjects in MCI group and 199 obese subjects in control group.

Results:

A correlation between increased serum UA level and decreased risk of MCI was found in all MCI patients and non-obese MCI patients ( OR 0.60, 95% CI 0.45-0.78; OR 0.42, 95% CI 0.29-0.62), but not in obese MCI patients ( OR 0.86, 95% CI 0.54-1.35). The levels of UA and hypersensitive C reactive protein (hs-CRP) in obese patients with MCI were higher than those in non-obese patients ( P<0.01). There was a linear positive correlation between serum UA and hs-CRP levels in obese patients with MCI ( r=0.505, P<0.01), but not in non-obese MCI patients ( r=0.053, P=0.385).

Conclusion:

A significant correlation between lower serum uric acid levels and higher risk of MCI in non-obese subjects was found. Inflammation caused by obesity may weaken this relationship.
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Endocrinology and Metabolism Ano de publicação: 2020 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Endocrinology and Metabolism Ano de publicação: 2020 Tipo de documento: Artigo