The fibrinogen Bβ-455G/A gene polymorphism associated with small-artery-occlusion cerebral infarction / 中华神经科杂志

ABSTRACT

Fibrinogen is a glycoprotein that has hemostatic and clotting effects and participates in the process of thrombosis, and also participates in the process of mediating inflammatory response. At present, the study on the relationship between fibrinogen, fibrinogen Bβ-455G/A gene polymorphism and ischemic stroke has attracted people′s attention, but there are few relevant reports, especially the study on the relationship between fibrinogen, fibrinogen Bβ-455G/A gene polymorphism and small-artery-occlusion cerebral infarction, and the conclusions are inconsistent. This paper reviews the recent studies on the correlation between fibrinogen, fibrinogen Bβ-455G/A gene polymorphism and ischemic stroke, mainly with small-artery-occlusion cerebral infarction.