Disruption of circadian rhythm in Parkinson′s disease / 中华神经科杂志

ABSTRACT

Parkinson′s disease (PD) is the common progressive neurodegenerative disorder affecting older adults. Alterations of the circadian system occur in PD patients. However, the molecular mechanisms and pathophysiological process remain elusive. Circadian rhythm is modulated by both internal and external factors and using bright light and melatonin as chronotherapeutic tools may be potential therapies to improve symptoms of PD in the future. This article reviewed the abnormal changes of circadian parameters in clinical symptoms of PD and the possible mechanisms of circadian rhythm to provide basis for exploring the therapeutic strategies of circadian rhythm in PD.