Research progress on the role of mRNA N6-methyladenosine methylation in the nervous system / 中华神经科杂志

ABSTRACT

N6-methyladenosine (m 6A), one of the most common types of eukaryotic mRNA methylation modification, is widely distributed in the nervous system and participates in important regulatory mechanisms for controlling gene expression. With the participation of related methylation-modifying enzymes and proteins, m 6A plays an important role in the growth and development of the nervous system, related functions, and the occurrence and development of diseases in the nervous system by affecting the "life cycle" of mRNA. This article briefly reviews the research progress on the role of mRNA m 6A methylation modification in neurological diseases and nervous system growth and development.