Anti-leucine-rich glioma-inactivated protein 1 and glutamic acid decarboxylase 65 antibodies double-positive autoimmune encephalitis complicated with vitiligo: a case report / 中华神经科杂志

ABSTRACT

Autoimmune encephalitis (AE) refers to a kind of encephalitis mediated by immune mechanism, which is one of adult symptomatic epilepsy due to unknown etiology. Early recognition has certain difficulty. AE patients with multiple antineuronal antibody co-existing are relatively rare. Clinical symptoms are more complex and variable, and can involve a wider range of immune system. A case of temporal lobe epilepsy with anti-leucine-rich glioma-inactivated protein 1 and glutamic acid decarboxylase 65 antibodies double-positive AE complicated by vitiligo and diabetes is reported. After immune shock and continuous immunotherapy, the patient completely recovered from encephalitis and diabetes, and vitiligo was improved obviously.