Aspirin in prevention of preeclampsia and its mechanism / 中华围产医学杂志

ABSTRACT

Current guidelines recommend that women with high risk factors for preeclampsia should take low-dose aspirin between 12 to 34 weeks of gestation (preferably before 16 weeks of gestation), in order to effectively reduce the risk of preeclampsia. The mechanism of aspirin in preventing preeclampsia includes lowering the ratio of thromboxane A 2 over prostacyclin; decreasing the plasma level of soluble Fms-like tyrosine kinase-1; increasing the proliferation and invasion of trophoblast, whilst inhibiting trophoblast apoptosis; and anti-inflammatory effects. This article reviews the progress on research regarding its mechanism.