Progress in association between high mobility group protein box 1 (HMGB1) and immune imbalance in primary Sj?gren′s syndrome / 中华微生物学和免疫学杂志

ABSTRACT

Primary Sj?gren′s syndrome (pSS) is a relatively common autoimmune systemic disease. The pathogenesis of pSS has not been fully elucidated. With the deepening of research, it is found that high mobility group protein box 1 (HMGB1) is associated with the pathogenesis of pSS, and immunomodulatory abnormalities have become a research hotspot. This article reviewed the association between HMGB1 and immune imbalance in the pathogenesis of pSS.