Comparison of therapeutic efficacy and safety of conventional radiotherapy and large-segment radiotherapy for patients with early breast cancer undergoing breast-conserving surgery / 肿瘤研究与临床

ABSTRACT

Objective:To explore the therapeutic efficacy and safety of conventional radiotherapy and large-segment radiotherapy in patients with early breast cancer undergoing breast-conserving surgery.Methods:A total of 84 early breast cancer patients undergoing breast-conserving surgery treated in Haikou People's Hospital from March 2013 to March 2015 were collected, and they were divided into the conventional group (40 cases) and the large segmentation group (44 cases) according to the radiotherapy method. The patients in the conventional group received conventional radiotherapy at a dose of 2 Gy/time, 25 times in total, with a total dose of 50 Gy, 42 d of total treatment; the patients in the large-scale group received large-scale radiotherapy at a dose of 2.66 Gy/time, 16 times in total, with a total dose of 42.56 Gy, 22 d of total treatment. The effect of radiotherapy, cosmetic effect and adverse reactions of patients in two groups was evaluated. The survival, local recurrence and distant metastasis were also analyzed.Results:There was no statistically significant difference in the total effective rate between the large segmentation group and the conventional group [90.9% (40/44) vs. 95.0% (39/40), χ2 = 1.626, P = 0.205], and there was no statistically significant difference in the excellent rate of beauty effect [90.9% (40/44) vs. 92.5% (37/40), χ2 = 0.069, P = 0.792]. There were no significant differences in the incidence of esophageal mucosal reaction, radiation-induced pneumonia, myelosuppression, advanced skin reaction and acute skin reaction between the conventional group and the large-scale group [2.5% (1/40) vs. 4.6% (2/44), χ2 = 0.255, P = 0.614; 2.5% (1/40) vs. 2.3% (1/44), χ2 = 0.005, P = 0.946; 52.5% (21/40) vs. 52.3% (23/44), χ2 = 0.001, P = 0.983; 2.5% (1/40) vs. 2.3% (1/44), χ2 = 0.005, P = 0.946; 85.0% (34/40) vs. 79.6% (35/44), χ2 = 0.425, P = 0.514). There were no significant differences in 3-year overall survival rate, local recurrence rate and distant metastasis rate between the large-scale segmentation group and the conventional group [90.0% vs. 90.9%, χ2 = 0.020, P = 0.904; 5.0% (12/40) vs. 2.3% (1/44), χ2 = 0.453, P = 0.501; 7.5% (3/40) vs. 6.3% (3/44), χ2 = 0.015, P > 0.05]. Conclusions:Compared with conventional segmented radiotherapy, large-segment radiotherapy regimen can achieve similar efficacy and safety when used as an adjuvant treatment for early breast cancer after breast-conserving surgery. It has the advantages of short treatment cycles and fewer radiotherapy treatments.