Effect of Tiluo Yangxue Mingmu Prescription on Visual Function，Vessel Density and Thickness of Retinal Nerve Fiber Layer of Optic Nerve in Glaucoma Patients / 中国实验方剂学杂志

ABSTRACT

Objective:To investigate the effect of Tiluo Yangxue Mingmu prescription on the improvement of visual function，and to analyze the effect on the vessel density and the thickness of retinal nerve fiber layer（RNFL） of optic nerve in glaucoma patients. Method:The clinical data of 234 eyes of 117 patients of primary glaucoma treated with Tiluo Yangxue Mingmu prescription from January 2017 to July 2020 were retrospectively analyzed. Fifty-seven eyes treated with the Tiluo Yangxue Mingmu prescription were reviewed as the treatment group，and 57 eyes that were not treated with the prescription matched in gender，age and course of treatment were selected as the control group. The changes of BCVA，mean sensitivity（MS） and mean deviation（MD） of visiual field before and after treatment were analyzed. Optical coherence tomography（OCTA） was used to analyze the changes of VD and thickness of RNFL of potic nerve before and after treatment. Result:After treatment，compared with that before treatment，BCVA was increased （P=0），MS was increased （P=0），MD was decreased（P=0.001），VD of the whole image（P=0），VD of the inside disc（P=0.004） and all subdivisions of peripapillary（P<0.05） was increased，the RNFL thickness（except inferior nasal area） was not significantly changed. After treatment，MS was increased（P=0.003） and MD was decreased（P=0.024） in treatment group compared with those before treatment. In the control group，there was no statistical difference in the changes of visual field indicators after treatment compared with that before treatment. Conclusion:For glaucoma patients whose intraocular pressure is stable within the range of target intraocular pressure，Tiluo Yangxue Mingmu prescription can improve the visual function and VD of optic nerve，but has no significant effect on RNFL thickness.