A case of gonadoblastoma in patient with mixed gonadal dysgenesis / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 1204-1208, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-87506
ABSTRACT
Gonadoblastoma occurs almost always in association with a Y chromosome cell line, and developes in one third of patients with Mixed gonadal dysgenesis. Removing of gonads of intersex patients with the Y chromosome is very important because of the strong association of the genesis of tumor in dysgenetic gonads with the presence of a Y chromosome. But it is always possible that an XY cell line could be missed, or that a fragment from Y chromosome could have been translocated and not discovered by chromosomal analysis. PCR with Y specific probe or Southern blotting would reveal the presence of a Y or a translocated fragment. We experienced an 18-year-old woman represent with primary amenorrhea who had 45,X/46,X,+mar. Y-specific PCR revealed that the marker chromosome was drived from Y chromosome. After both gonadectomy and clitorial recession, we found the gonadoblastoma in dysgenetic testis. So we report it with brief review of literatures.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Testículo
/
Cromossomo Y
/
Linhagem Celular
/
Southern Blotting
/
Reação em Cadeia da Polimerase
/
Gonadoblastoma
/
Amenorreia
/
Disgenesia Gonadal Mista
/
Gônadas
Limite:
Adolescente
/
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Ano de publicação:
2002
Tipo de documento:
Artigo
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