Efficacy of intravitreal injection of Aflibercept <i>vs</i> Ranibizumab in the treatment of diabetic retinopathy / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
;
(12): 757-763, 2021.
Artigo
em Inglês
| WPRIM
| ID: wpr-875994
ABSTRACT
@#AIM:
To systematically assess the effect of intravitreal injection of Aflibercept or Ranibizumab in the treatment of diabetic retinopathy(DR)by using Meta-analysis.<p>METHODS:
PubMed, MEDLINE, Web of Science, Cochrane, Nature Series, ScienceDirect, and ESI Databases were searched until May 2019. Ten studies included a total of 1 240 participants with DR had been administered in the Meta-analysis. Aflibercept or Ranibizumab <i>via</i> intravitreal injection. After selecting useful information, we used RevMan 5.3 to further analysis. Systematic review and Meta-analysis were used to design.<p>RESULTS:
The pooled results showed that central macular thickness(CMT)was significantly reduced(<i>P</i><0.00001)in the intravitreous Aflibercept group(IVA); compared with the intravitreous Ranibizumab group(IVR), which did not greatly improve best corrected visual acuity(BCVA)and visual acuity(VA).<p>CONCLUSION:
This Meta-analysis suggests that both IVA and IVR are effective in the treatment of DR patients. Specifically, Aflibercept shows better improvements in CMT, while Ranibizumab is beneficial in increasing BCVA or VA.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Revisões Sistemáticas Avaliadas
Idioma:
Inglês
Revista:
International Eye Science
Ano de publicação:
2021
Tipo de documento:
Artigo
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