Clinical Manifestations of Avellino Corneal Dystrophy Diagnosed by Non-invasive Genetic Test
Journal of the Korean Ophthalmological Society
;
: 1431-1436, 2008.
Artigo
em Coreano
| WPRIM
| ID: wpr-8760
ABSTRACT
PURPOSE:
To introduce a new genetic method for the diagnosis of Avellino corneal dystrophy (ACD), which is non-invasive and can be easily performed on an outpatient basis, and to evaluate the relationship between the degree of corneal opacity and age or sex.METHODS:
A genetic study was performed on 11 patients who had a specific corneal opacity by slit-lamp examination and on four normal patients by using a specific adhesive tape to obtain epidermal keratinocytes. Corneal dystrophy was diagnosed according to the genetic study.RESULTS:
All 11 patients were confirmed as having heterozygous ACD. Heterozygous ACD patients were classified into five stages trace, mild, moderate, severe, or very severe, based on slit-lamp photography status. Corneal stages had no relationship with sex (p=0.982), but the severity of ACD increased with age (p=0.005).CONCLUSIONS:
A non-invasive sticker-type genetic study kit, the "U-gene test" is a good method to diagnose corneal dystrophy genetically. Avellino corneal dystrophy becomes more severe over time but has no relationship with sex.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pacientes Ambulatoriais
/
Fotografação
/
Queratinócitos
/
Adesivos
/
Distrofias Hereditárias da Córnea
/
Opacidade da Córnea
Tipo de estudo:
Estudo diagnóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Ophthalmological Society
Ano de publicação:
2008
Tipo de documento:
Artigo
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