Research advances in anti-hepatitis B virus therapy targeting covalently closed circular DNA / 临床肝胆病杂志
Journal of Clinical Hepatology
;
(12): 1189-1192., 2021.
Artigo
em Chinês
| WPRIM
| ID: wpr-876665
ABSTRACT
The incurable chronic infection caused by hepatitis B virus (HBV) is the major health burden worldwide. Covalently closed circular DNA (cccDNA) exists in the nucleus of infected cells as a stable minichromosome, and when a new therapy realizes inactivation or eliminates persistent cccDNA in infected hepatocytes, the natural process of chronic infection and long-term antiviral therapy will no longer exist. This article introduces the methods targeting cccDNA, such as gene editing and epigenetic modification, so as to achieve the complete cure of HBV infection.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Clinical Hepatology
Ano de publicação:
2021
Tipo de documento:
Artigo
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