Clinical characteristics and biochemical parameters of diabetic nephropathy patients / 公共卫生与预防医学

ABSTRACT

Objective To study the clinical characteristics and biochemical parameters of diabetic nephropathy patients , and to understand the occurrence of chronic complications such as kidney diseases. Methods From February 1, 2017 to November 30, 2020, 352 patients with type 2 diabetes aged between 35 and 70 years with diabetes lasting more than 10 years were selected for study. According to the estimated glomerular filtration rate (EGFR), the patients were divided into two groups, in which the patients with EGRF were less than 15mL/min/1.73m2, and they suffered from ESRD and underwent hemodialysis. The subjects in the second group were reclassified into three groups according to their urinary albumin excretion, including microalbuminuria, massive albuminuria and end-stage renal disease (ESRD). To analyze the hematological and biochemical parameters in different stages of diabetic nephropathy. Results Among 232 patients with nephropathy, 96 cases (41.38%) had microalbuminuria, 43 cases (18.53%) had albuminuria and 91 cases (39.22%) had end-stage renal disease (ESRD).The remaining 120 patients (34.09%) did not develop nephropathy. Patients with kidney disease are older, with an average age (SD) of 55.62 6.00 years, and diabetes lasts longer (19.04 6.33 years). The BMI of patients with kidney disease is lower than that of patients without kidney disease. Among them, insulin resistance, elevated uric acid level, low red blood cell count and low hemoglobin level are related to the significantly increased risk of albuminuria and ESRD. Elevated levels of uric acid and LDH are associated with significantly increased risk of microalbuminuria and ESRD, while elevated red blood cell distribution width is associated with significantly increased risk of ESRD. Conclusion Diabetic nephropathy is related to insulin resistance, changes of liver enzymes and uric acid, as well as abnormal red blood cell count and red blood cell shape, which need to be monitored frequently by diabetic nephropathy patients.