Effect of Horse Oil on Anti-bacterial, Inflammatory Cytokines, and Type I Collagen Expressions in Human HaCaT Keratinocytes and Fibroblasts / 대한피부과학회지
Korean Journal of Dermatology
;
: 1-6, 2014.
Artigo
em Coreano
| WPRIM
| ID: wpr-87777
ABSTRACT
BACKGROUND:
Anti-inflammation, anti-bactericidal, and collagen synthesis are important for health skin conditions. However, the effect of horse oil on anti-inflammation, anti-bactericidal, and collagen synthesis is largely unknown.OBJECTIVE:
The aim of this study was to evaluate the anti-bactericidal, anti-inflammatory, and synthesis of type I collagen of horse oil.METHODS:
Anti-bacterial effect was evaluated by disc diffusion test. Expressions of inflammatory cytokines were studied by RT-PCR analysis, real time PCR. Type I collagen expression was evaluated by Western blot in human HaCaT kertinocytes and fibroblasts.RESULTS:
Our data showed that horse oil exerted anti-bacterial effect on P.acnes and S.aureus. Expression of IL-10 was increased by horse oil-treated HaCaT cells. In addition, increased expression of type I collagen was observed in horse oil-treated human skin fibroblasts.CONCLUSION:
Horse oil exerts an anti-bactericidal effect against P.acnes and S.aureus. In addition, anti-inflammatory and anti-aging effects of horse oil will be mediated by up-regulation of IL-10 and type I collagen, respectively.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
Queratinócitos
/
Regulação para Cima
/
Western Blotting
/
Citocinas
/
Colágeno
/
Interleucina-10
/
Colágeno Tipo I
/
Difusão
/
Reação em Cadeia da Polimerase em Tempo Real
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
2014
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS