The metabolic networks of ferroptosis and links to lung diseases / 生理学报
Acta Physiologica Sinica
;
(6): 566-574, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-878202
ABSTRACT
Ferroptosis is a newly discovered non-apoptotic form of regulated cell death driven by iron-dependent lipid peroxidation. The present studies have shown that many metabolic processes and homeostasis are affected by ferroptosis. It is related to many lung diseases, including acute lung injury, chronic obstructive pulmonary disease and pulmonary fibrosis, etc. Currently, the research on ferroptosis is still in its infancy. Previous studies have confirmed that ferroptosis is regulated by a variety of genes, and the mechanism is complex, mainly involving iron homeostasis and lipid peroxidation metabolism. This review summarizes some regulation networks of metabolic processes associated with ferroptosis and discusses the roles of ferroptosis in the pathophysiological progression of many lung diseases. We expected to provide new ideas and references for the treatment of these diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Peroxidação de Lipídeos
/
Doença Pulmonar Obstrutiva Crônica
/
Redes e Vias Metabólicas
/
Ferroptose
/
Ferro
Limite:
Humanos
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2020
Tipo de documento:
Artigo
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