Progress of epithelial-mesenchymal transition in respiratory system and the modulatory mechanism of cell adhesion / 生理学报
Acta Physiologica Sinica
;
(6): 605-616, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-878206
ABSTRACT
Epithelial-mesenchymal transition (EMT) plays an important role in the development and pathogenesis of respiratory system. Epithelial cells are characterized by well-developed, intercellular contacts, whereas EMT triggers the sequential destabilization of cell-cell adhesive junctions. The dynamic remodeling of the epithelial cell adhesion molecules is important for maintaining the integrity and normal function of epithelium. This paper reviews the research progress of EMT in lung development, lung injury repair and chronic lung diseases, and summarizes the effect of cell junctions and cell adhesion molecules on EMT molecular events.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sistema Respiratório
/
Moléculas de Adesão Celular
/
Adesão Celular
/
Células Epiteliais
/
Transição Epitelial-Mesenquimal
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2020
Tipo de documento:
Artigo
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