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Roles of smooth muscle 22α in vascular homeostasis and vascular remodeling / 生理学报
Acta Physiologica Sinica ; (6): 82-88, 2021.
Artigo em Chinês | WPRIM | ID: wpr-878238
ABSTRACT
The research on the molecular mechanism of vascular injury has been a hot topic in recent years since the mechanism can be targeted for the treatment of vascular injury diseases. A large number of studies have found that vascular injury, repair and pathological remodeling are closely related to phenotype switching, abnormal proliferation and migration, and apoptosis of vascular smooth muscle cells (VSMCs). Smooth muscle 22α (SM22α) is a shape change and transformation sensitive F-actin-binding protein. SM22α decorates the contractile filament bundles within cultured VSMCs exhibiting differentiated phenotypes. In addition, SM22α is involved in regulation of cell signaling pathways related to vascular homeostasis and vascular remodeling. Here, we reviewed the recent research progress of SM22α in vascular homeostasis and remodeling.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenótipo / Células Cultivadas / Miócitos de Músculo Liso / Proliferação de Células / Remodelação Vascular / Homeostase / Proteínas Musculares / Músculo Liso Vascular Limite: Humanos Idioma: Chinês Revista: Acta Physiologica Sinica Ano de publicação: 2021 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Fenótipo / Células Cultivadas / Miócitos de Músculo Liso / Proliferação de Células / Remodelação Vascular / Homeostase / Proteínas Musculares / Músculo Liso Vascular Limite: Humanos Idioma: Chinês Revista: Acta Physiologica Sinica Ano de publicação: 2021 Tipo de documento: Artigo