Positive inotropic effect of phosphodiesterase type 9 inhibitor PF-04449613 in rats and its underlying mechanism / 生理学报
Acta Physiologica Sinica
;
(6): 275-285, 2021.
Artigo
em Chinês
| WPRIM
| ID: wpr-878256
ABSTRACT
This study aimed to explore the positive inotropic effect of phosphodiesterase type 9 (PDE9) inhibitor PF-04449613 in ratsand its cellular and molecular mechanisms. The heart pressure-volume loop (P-V loop) analysis was used to detect the effects of PF-04449613 on rat left ventricular pressure-volume relationship, aortic pressures and peripheral vessel resistance in healthy rats. The Langendorff perfusion of isolated rat heart was used to explore the effects of PF-04449613 on heart contractility. The cardiomyocyte sarcoplasmic reticulum (SR) Ca
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Inibidores de Fosfodiesterase
/
Retículo Sarcoplasmático
/
Cálcio
/
Diester Fosfórico Hidrolases
/
Canal de Liberação de Cálcio do Receptor de Rianodina
/
Miócitos Cardíacos
/
Contração Miocárdica
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Physiologica Sinica
Ano de publicação:
2021
Tipo de documento:
Artigo
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