Three-dimensional chromosome conformation capture and its derived technologies / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 2040-2050, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-878464
ABSTRACT
Linear chromatin is compacted into eukaryotic nucleus through a complex and multi-layered architecture. Consequently, chromatin conformation in a local or long-distance manner is strongly correlated with gene expression. Chromosome conformation capture (3C) technology, together with its variants like 4C/5C/Hi-C, has been well developed to study chromatin looping and whole genome structure. In this review, we introduce new technologies including chromosome capture combined with immunoprecipitation, nuclei acid-based hybridization, single cell and genome sequencing, as well as their application.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cromatina
/
Núcleo Celular
/
Técnicas Genéticas
/
Cromossomos
/
Genoma
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2020
Tipo de documento:
Artigo
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