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Effects of Vitamin D Supplementation on Serum Lipid Profiles and Neonatal Outcomes in Gestational Diabetes Mellitus:a Meta-analysis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae ; (6): 82-91, 2021.
Artigo em Chinês | WPRIM | ID: wpr-878703
ABSTRACT
Objective To evaluate the effects of vitamin D supplementation on serum lipid profiles and neonatal prognosis in gestational diabetes mellitus(GDM)patients.Methods The electronic databases including PubMed,Web of Science,Embase,CNKI,and Wanfang Data were searched from inception to February 1,2020.All randomized controlled trials that compared vitamin D supplementation with placebo or without supplementation for GDM women were included.Paper selection,data extraction,meta-analysis and sensitivity analysis were conducted independently by two authors.Risk of bias was assessed using the Cochrane Risk of Bias Tool.The data were analyzed in RevMan 5.3 software and Stata 12.0.Results Totally 17 randomized controlled trials involving 1432 patients(704 in the intervention group and 728 in the control group)were included in the meta-analysis.The results showed that vitamin D supplementation significantly reduced serum total cholesterol [MD=-6.11,95% CI=(-7.17,-5.04)],low-density lipoprotein cholesterol [MD=-10.80,95% CI=(-14.72,-6.89)],and triglyceride [MD=-8.11,95% CI=(-10.09,-6.13)],while significantly increased serum 25-hydroxyvitamin D3 level [MD=45.45,95% CI=(41.98,48.92)] and high-density lipoprotein cholesterol [MD=2.77,95% CI=(1.59,3.96)].In addition,vitamin D supplementation significantly reduced the incidence rate of hyperbilirubinemia [RR=0.49,95% CI=(0.35,0.68)],premature birth [RR=0.44,95% CI=(0.27,0.72)],and neonatal hospitalization [RR=0.44,95% CI=(0.29,0.67)].Conclusions Vitamin D supplementation may regulate the serum lipid profiles in patients with GDM and reduce the incidence of adverse neonatal outcomes.More high-quality RCTs are needed to confirm the findings in our study.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Vitamina D / Vitaminas / Ensaios Clínicos Controlados Aleatórios como Assunto / Diabetes Gestacional / Suplementos Nutricionais / Nascimento Prematuro Tipo de estudo: Ensaio Clínico Controlado / Estudo prognóstico / Revisões Sistemáticas Avaliadas Limite: Feminino / Humanos / Recém-Nascido / Gravidez Idioma: Chinês Revista: Acta Academiae Medicinae Sinicae Ano de publicação: 2021 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Vitamina D / Vitaminas / Ensaios Clínicos Controlados Aleatórios como Assunto / Diabetes Gestacional / Suplementos Nutricionais / Nascimento Prematuro Tipo de estudo: Ensaio Clínico Controlado / Estudo prognóstico / Revisões Sistemáticas Avaliadas Limite: Feminino / Humanos / Recém-Nascido / Gravidez Idioma: Chinês Revista: Acta Academiae Medicinae Sinicae Ano de publicação: 2021 Tipo de documento: Artigo