Biotransformation and enzymatic mechanism of protoberberine alkaloids / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 5884-5889, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-878850
ABSTRACT
Protoberberine alkaloids belong to the quaternary ammonium isoquinoline alkaloids, and are the main active ingredients in traditional Chinese herbal medicines, like Coptis chinensis. They have been widely used to treat such diseases as gastroenteritis, intestinal infections, and conjunctivitis. Studies have shown that structural modification of the protoberberine alkaloids could produce derivative compounds with new pharmacological effects and biological activities, but the transformation mechanism is not clear yet. This article mainly summarizes the researches on the biotransformation and structure modification of protoberberine alkaloids mainly based on berberine, so as to provide background basis and new ideas for studies relating to the mechanism of protoberberine alkaloids and the pharmacological activity and application of new compounds.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Berberina
/
Alcaloides de Berberina
/
Biotransformação
/
Coptis
/
Alcaloides
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2020
Tipo de documento:
Artigo
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