A case of malignant granular cell tumor / 대한내과학회지

ABSTRACT

Granular cell tumor is a relatively uncommon and usually benign neoplasm of the soft tissue. Most cases are benign, and only over 40 cases of malignant granular cell tumors were reported by the presence of metastases in the world literature. A 54-year-old woman with cough, mild exertional dyspnea and abnormal chest radiography was admitted to our hospital. Four years ago, the patient underwent a surgical excision of the mass at the left thigh. The lesion was diagnosed as a granular cell tumor. Chest and abdominal CT scans showed multiple variable sized pulmonary and hepatic nodules. Multiple osteoblastic and osteolytic bone lesions were also noted on chest and abdominal CT scans. Ultrasonography-guided biopsy of the pulmonary and hepatic nodule were done. The histologic examination revealed a tumor growing in nests and sheets. Tumor cells contained abundant eosinophilic granular cytoplasm which was PAS-positive and resistant to diastase digestion. After histologic examination, we diagnosed as a malignant granular cell tumor. We report a case of malignant granular cell tumor with multiple pulmonary, bone and hepatic metastases.