Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 590-601, 2020.
Artigo
em Inglês
| WPRIM
| ID: wpr-879702
ABSTRACT
The mammalian epididymis not only plays a fundamental role in the maturation of spermatozoa, but also provides protection against various stressors. The foremost among these is the threat posed by oxidative stress, which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids, proteins, and nucleic acids. In mice, the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5 (GPX5) as a major luminal scavenger in the proximal caput epididymidal segment. Accordingly, the loss of GPX5-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx5
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Inglês
Revista:
Asian Journal of Andrology
Ano de publicação:
2020
Tipo de documento:
Artigo
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