Clinical significance of minimal residual disease in B-lineage acute lymphoblastic leukemia pediatric patients with different fusion gene backgrounds / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1279-1285, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-879790
ABSTRACT
OBJECTIVE@#To study the clinical significance of minimal residual disease (MRD) in B-lineage acute lymphoblastic leukemia (B-ALL) pediatric patients with different fusion gene backgrounds.@*METHODS@#A retrospective analysis was performed on the medical data of 441 B-ALL children who were treated from January 2008 to April 2015. Among the 441 children, 336 had negative fusion gene, 79 had positive @*RESULTS@#In patients with negative fusion gene, the positive MRD group had significantly lower overall survival (OS) rate and event-free survival (EFS) rate (@*CONCLUSIONS@#MRD has the most definite prognostic significance in pediatric B-ALL patients with negative fusion gene, while it has unsatisfactory prognostic significance in those with positive
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Leucemia-Linfoma Linfoblástico de Células Precursoras B
/
Proteínas de Fusão Oncogênica
/
Estudos Retrospectivos
/
Neoplasia Residual
/
Proteínas de Homeodomínio
/
Intervalo Livre de Doença
/
Subunidade alfa 2 de Fator de Ligação ao Core
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Criança
/
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2020
Tipo de documento:
Artigo
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