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Effect and mechanism of vascular endothelial growth factor-A on pulmonary vascular remodeling in neonatal rats with hypoxic pulmonary hypertension / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 103-110, 2021.
Artigo em Chinês | WPRIM | ID: wpr-879817
ABSTRACT
OBJECTIVE@#To study the role of vascular endothelial growth factor-A (VEGF-A) in pulmonary vascular remodeling in neonatal rats with hypoxic pulmonary hypertension (HPH) by regulating survivin (SVV).@*METHODS@#A total of 96 neonatal rats were randomly divided into three groups HPH+VEGF-A group, HPH group, and control group. Each group was further randomly divided into 3-, 7-, 10-, and 14-day subgroups (@*RESULTS@#The HPH group had a significantly higher mean RVSP than the control and HPH+VEGF-A groups at each time point (@*CONCLUSIONS@#Prophylactic intratracheal administration of exogenous VEGF-A in neonatal rats with HPH can inhibit pulmonary vascular remodeling and reduce pulmonary arterial pressure by upregulating the expression of SVV in the early stage of hypoxia. This provides a basis for the interventional treatment of pulmonary vascular remodeling in neonatal HPH.
Assuntos
Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Artéria Pulmonar / Ratos Wistar / Fator A de Crescimento do Endotélio Vascular / Remodelação Vascular / Hipertensão Pulmonar / Animais Recém-Nascidos / Hipóxia Limite: Animais Idioma: Chinês Revista: Chinese Journal of Contemporary Pediatrics Ano de publicação: 2021 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Artéria Pulmonar / Ratos Wistar / Fator A de Crescimento do Endotélio Vascular / Remodelação Vascular / Hipertensão Pulmonar / Animais Recém-Nascidos / Hipóxia Limite: Animais Idioma: Chinês Revista: Chinese Journal of Contemporary Pediatrics Ano de publicação: 2021 Tipo de documento: Artigo